智能响应抗菌材料与软组织损伤修复团队
团队负责人：张翔宇
团队成员：李永锋，王颖，文美玲，闫佳辉等
研究方向：
（1）外场智能响应抗菌材料
（2）碳基生物医用纳米材料
（3）高分子响应型生物材料
（4）无机介孔医用纳米材料
团队简介：
团队致力于生物医用抗菌材料开发与成果转化。现有教授2人，讲师3人，共建省重点实验室1个，省科技创新领军人才1人。近年来承担国家级、省部级及企业委托项目30余项，发表论文100余篇，获山西省科学技术奖2项。研发的抗菌纳米材料已在新型功能纺织品及洗护领域示范应用，为企业产生经济效益数千万元。
代表性科研项目及奖项：
1. 国家自然科学基金，52171240，纳米结构介导近红外二区光辅助钛植入体高效抗菌表界面的研究，2022~2025。
2. 国家自然科学基金，31700834，钛表面间距可控纳米棒阵列的构建及其细胞/细菌响应机制研究，2018~2020。
3. 国家自然科学基金， 22278291, 氧空穴金属氧化物/生物质织物衍生炭基微管网络结构柔性电极的构筑及其储能机理，2023~2026。
4. 校企合作课题，抗菌碳纳米材料结构优化及其在新型功能纺织品和美妆洗护领域应用研究，180万，2024~2029。
5. 校企合作课题，自动化煎药设备煎药工艺与纳米粒子浓度和成分关系研究，150万，2025-2028。
6. 校企合作课题，兼具导电和太阳能光热除冰性能的超疏水涂层研发与应用，88.5万，2024~2026。
7. 光辅助高效抗菌材料的构建及组织修复，山西省科学技术奖自然科学类二等奖，2023。
8. 医用钛基植入体表面活性涂层构建与骨整合机制，山西省科学技术奖自然科学类二等奖，2021。
9. 新型高效抗菌纳米材料研究与应用，山西省科技创新领军人才项目，2026。
代表性文章
1. Guannan Zhang; Zehao Li; Ying Lu; Jianbo Song; Xingyu Liang; Peide Han;
2. Xiaohong Yao; Yongqiang Yang; Xiangyu Zhang; A herbal-Piezoelectric heterojunction strategy to potentiate bacterial cuproptosis-like death and remodel the inflammatory microenvironment in infection-associated implant osteomyelitis, Advanced Science,2025, e06362.
3. Guannan Zhang; Zehao Li; Menlin Sun; Ying Lu; Jianbo Song; Wangping Duan; Xiaobo Huang; Ruiqiang Hang; Xiaohong Yao; Paul K Chu; Xiangyu Zhang; Nanostructure-mediated photothermal effect for reinforcing physical killing activity of nanorod arrays, Advanced Science, 2024, 2411997.
4. Hao Cheng; Yongqiang Yang; Yueyue Wang; Jiqiang Guo; Xiong Jiao; Di Huang; Meiwen An; Xiaohong Yao; Paul K Chu; Xiangyu Zhang; Microwave-responsive nanoplatform with robust ROS generation and inhibiting effects of two-component system and quorum sensing for the treatment of MRSA-induced osteomyelitis, Advanced Functional Materials, 2024, 2405421.
5. Menglin Sun; Jiameng Wang; Xiaobo Huang; Ruiqiang Hang; Peide Han; Jiqiang Guo; Xiaohong Yao; Paul K Chu; Xiangyu Zhang; Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection, Biomaterials, 2024, 307, 122532.
6. Tao Xu; Hao Cheng; Hailiang Pei; Jiameng Wang; Yiwei Shi; Xiangyu Zhang; Di Huang; Emodin enhanced Microwave-responsive heterojunction with powerful bactericidal capacity and immunoregulation for curing bacteria-infected osteomyelitis, Advanced Science, 2024, 2409979.
7. Jiameng Wang; Hao Cheng; Yongqiang Yang; Jing Shi; Weiyi Chen; Peide Han; Xiaohong Yao; Bin Tang; Wangping Duan; Pengcui Li; Xiaochun Wei; Paul K Chu; Xiangyu Zhang；An injectable, self-healing composite hydrogel with enhanced near-infrared photo-antibacterial therapeutic effects for accelerated wound healing, Chemical Engineering Journal, 2023, 452, 139474.
8. Hao Cheng; Jiameng Wang; Yongqiang Yang; Huixian Shi; Jing Shi; Xiong Jiao; Peide Han; Xiaohong Yao; Weiyi Chen; Xiaochun Wei; Paul K Chu; Xiangyu Zhang; Ti3C2TX MXene modified with ZnTCPP with bacteria capturing capability and enhanced visible light photocatalytic antibacterial activity, Small, 2022, 2200857.
9. Guannan Zhang; Zhuangzhuang Wu; Yongqiang Yang; Jing Shi; Jia Lv; Yi Fang; Zhen Shen; Zhi Lv; Pengcui Li; Xiaohong Yao; Weiyi Chen; Xiaochun Wei; Paul K. Chu; Xiangyu Zhang, A multifunctional antibacterial coating on bone implants for osteosarcoma therapy and enhanced osteointegration, Chemical Engineering Journal, 2022, 428: 131155.
10. Guannan Zhang; Yongqiang Yang; Jing Shi; Xiaohong Yao; Weiyi Chen; Xiaochun Wei; Xiangyu Zhang; Paul K Chu; Near-infrared light II - assisted rapid biofilm elimination platform for bone implants at mild temperature, Biomaterials, 2021, 269: 120634.
11. Xiangyu Zhang; Guannan Zhang; Maozhou Chai; Xiaohong Yao; Weiyi Chen; Paul K. Chu; Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant, Bioactive Materials, 2021, 6(1): 12-25.
